PHENOTYPE OF TRANSGENIC MICE CARRYING A VERY LOW COPY NUMBER OF THE MUTANT HUMAN G93A SUPEROXIDE DISMUTASE-1 GENE ASSOCIATED WITH AMYOTROPHIC LATERAL SCLEROSIS.

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease of the motor neuron.While most cases of ALS are sporadic, 10% are familial (FALS) with 20% of FALS caused by a mutation in the gene that codes for the enzyme Cu/Zn superoxide dismutase (SOD1).There is variability in sporadic ALS as well as FALS where even within the same

Abstract There is growing evidence that adipocytes play important roles in the progression of multiple cancers.Moreover, in obesity, adipocytes alter their original functions and contribute to the metabolic and inflammatory changes of adipose tissue microenvironment, hyfrodol which can further enhance tumor development.At present, the roles of adip

Testicular (germ cell) cancer is hyfrodol a model of a chemocurable malignancy and tends to have a favourable prognosis even in advanced stages due to exquisite sensitivity to platinum-based chemotherapy.However, both acute and longer-term toxicities of multiagent chemotherapy remain significant as causes of morbidity, very occasionally mortality,